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South Carolina has consistently had one of the nation’s lowest rates of return on its investment portfolio for the state’s public servants

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

including judges, teachers, police officers, firefighters, and other state and local government employees. At the moment, the South Caroli

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

na Retirement System for public servants only earns enough money on investments to contribute a mere seventy-two (.72) cents of each dollar

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

the state will owe retired employees in the coming years. And folks you guessed it, the remaining twenty-eight (.28) cents owed to these

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

retirees will no doubt come from you, me, and the rest of the working state-the taxpayers. We will have to make up the deficit.

Lucky for

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

all of us, those of us who turned out to vote- on that rainy day in the upstate and I commend you all- and all over the state, voted to am

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

end our state constitution by removing restrictions that have been responsible for the state’s lack of funds -in grand total of $9.1 billio

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

n- in the billions – in future obligations to our retirees. This resounding “yes” to the recent Question 3a on the ballot eliminates the 1

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

9th century restrictions that the South Carolina Constitution placed on investments made by the S.C. Retirement Commission with the money t

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

hat our state and local government employees paid into the system.

By amending our constitution the state can diversify its investment por

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

tfolio. By removing restrictions on investment strategies, the state now is able to invest in privately held companies as well as internat

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

ional companies. Before, the state’s constitution limited South Carolina’s equity investments to U.S. based companies on U.S. national exc

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

hanges. Now some of you think that foreign stocks and privately held companies should be avoided. However, by allowing these kinds of inv

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

estments, the dismal performance of the S.C. Retirement system will definitely improve. This past year our state earned a mere 5.1 percent

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

return on the investments made by commissions in U.S stocks, certificates of deposit, and Treasury bonds while the median earnings for t

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

he rest of the country over the same period was 11.9 percent. Shocking folks because the rest of the country has already been investing in

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

foreign stocks, real estate, and privately held companies. As we all know the risk decreases with a wider range of responsible investment

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

s-when one category declines, another invariably performs better, thus profiting overall.

Now with restrictions lifted the S.C. Retirement

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

commission should be able to earn a bigger return and perhaps we can become one of the finest in the nation and as we all know nothing cou

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

ld be finer than to be in Carolina. Thanks to all of you who came out to vote and keep up the good work as it’s all in our best interests.

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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