Actual - Real Estate

Last week I wrote, “As well as can be expected,” about the Sacramento real estate market and how it performed in January. One of the larg

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

er communities in the Sacramento area is Roseville in Placer County.

According to the Sac Bee real estate charts there were 101 homes sol

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

d in Roseville during the first month of 2007. This was an expected decline from the December where we have a number of transactions that

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

are closed before year end. The drop in activity from December to January was 19 percent. The number of homes sold this January is the

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

same as sold in January 2006, 101 sales.

Taking a closer look at Roseville by using the three zip codes reveals the following:

Sales Act

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

vity Jan-07 Jan-06

by Zip Code Sales % chg. Sales % chg.

95661 17 -19.0% 21 -19.0%

95678 33 -19.5% 41 -19.5%

95747 51 30.8% 39 30.8%

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

101 0.0% 101

The changes in median prices from December 2006 to January 2007 show, in zip code 95661, an increase from $400,000

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

to $436,000. The 95747 area also showed a month-over-month increase of $27,000 to $457,000. In the 95678 area the median declined $30,00

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

0 during the same period to $320,000. The following chart details the changes from January 2006.

Median Price Jan-07

by Zip Code Med. $

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

% chg.

95661 436,000 -0.7%

95678 320,000 -20.0%

95747 457,114 5.3%

The median price paid per square foot was down year-over-year in a

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

l three Roseville zip codes but one area, 95661, had an increase from the previous month. The median price paid per square foot in the 95

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

661 area increased from $224.10 in December to a January figure of $228.49 but was still down 10.3 percent from the previous January. In

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

zip code area 95678 the month-over-month decline of $3.39 per square foot resulted in median of $226.24 which was 12.4 percent below what

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

it was last January. Finally in zip code 95747 we saw decline from December in the amount of $2.08 to $224.74 which is 11.7 percent decli

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

ne from January 2006.

Seeing the level of activity drop from December to January was expected but not having an increase from January 200

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

was a bit disappointing. In looking at median prices the price per square foot is a good tool to gauge where prices are at and where the

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

y may likely go. Although all three Roseville zip codes showed double digit percentage declines from last year the changes over the last

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

month are less severe and in one case even had an increase. I do believe we are starting to see prices stabilize and if inventory does no

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

t significantly spike upwards over the next few months prices should start to increase modestly.

As I said in the overall review of Janua

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

ry, the real estate activity for the month was about all we could expect and it is still too early to determine how the year will turn out

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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