Actual - Real Estate

Concrete is placed into a form in a wet condition. Through a process called hydration,

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

the water in the mix makes the cement harden. Water is released during hydration, causi

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

g the concrete mass to shrink. In fact, on average the concrete shrinks dimensionally a

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

out 1/16 of an inch in ten feet (0.4 centimeters in 3 meters). Depending on the shape,

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

ize, and other factors, any concrete mass may visibly show cracking due to shrinkage.

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

enerally, concrete shrinkage and cracking is minimized by reducing the water in the con

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

rete mix, protecting the fresh concrete during the first seven days from excessive temp

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

eratures and water evaporation, and reinforcing it. Note that reinforcing does not stop

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

concrete from cracking; it keeps small cracks from getting bigger.

Anyone who thinks c

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ncrete is inferior because it has cracked does not understand that all concrete

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

racks because it shrinks as it hardens. The best strategy is to figure out how to minim

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

ze cracking and control where it cracks since it is going to anyway.

Talk to your home

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

builder about how he intends to control or reduce cracking of concrete in your new home

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

Here are six ways:

• In concrete slabs, consider using “fiber mesh” or installing wir

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

e (or bar) reinforcing horizontally in the middle third (between the top and bottom).

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

Reduce the amount of water in the concrete mixture and/or increase the cement content.

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

• Protect fresh concrete from excessive wind, sun, and freezing for the first seven da

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

s.

• Use water curing methods or apply a liquid membrane curing compound.

• Make sure

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

the ground or subgrade under concrete is firm and relatively dry.

• Weaken the concret

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

along specific lines with some type of control joint so it cracks where you want it to

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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