Actual - Real Estate

This means that anything above 80% of financing will cost you significantly more. However, with 80/20 mortgage loans you can save on mortgage insur

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

ance. 80/20 mortgage loans are actually two loans in one. The first one being the actual mortgage loan that will finance the 80% of the property’

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

value thus not requiring private mortgage insurance and the other one will provide funds equivalent to 20% of the property’s value in the form of

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

a second mortgage or home equity loan.

Avoiding Payment of Private Mortgage Insurance (PMI)

These loans or combination of loans solve a

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

roblem that turned 100% financing mortgage loans into a really heavy burden. Any loan that finances above 80% of the value of a property needs to i

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

nclude private mortgage insurance in order to cover for the repayment of the loan if anything happens. Thus, this combination of loans provides 100

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

financing without the need of Private Mortgage Insurance.

Private mortgage insurance is not required because the actual mortgage only finances 80

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

% of the value of the property. The rest of the asset’s value is financed with a second mortgage or home equity loan that cover’s for the remaining

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

20% without the need of Private mortgage insurance either.

Private Mortgage Insurance

Private mortgage insurance protects the lender agai

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

nst any loss in the event of default on the mortgage loan. The insurance is similar to government agencies insurances like FHA with the sole differ

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

nce that it is meant for private mortgages only. The premium is paid by the borrower and is usually included on the mortgage’s monthly payments.

U

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

sually this extra charge can be bypassed by offering a substantial down payment and thus not requiring more than 80% of the funds needed to purchas

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

the property that is used as collateral for the loan. That’s why most applicants try to raise at least 20% of the value of the property in order t

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

o avoid having to pay the private mortgage insurance premium that is rather expensive.

A Matter Of Costs

Nothing comes for free and obtai

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

ing the additional financing through 80/20 mortgage loans is not the exception. The home equity loan that grants the funds needed for the 20% down

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

payment comes with higher interest rates, a shorter repayment program and generally less advantageous terms than the home loan. This is due to the

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

act that even that home equity loans are secured loans, there is a greater risk of defaulting on a home equity loan than on a home loan.

However,

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

when comparing the costs of private mortgage insurance and the additional amount that you’ll have to pay for the home equity loan, you’ll understan

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

why these loans are becoming so popular. Even with the additional costs that they repr

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

esent, you’ll still save a lot of money by not having to pay the private mortgage insurance premiums every month through the whole life of the loan

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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