Actual - Writing and Speaking

I live in a country where *men are MEN. They walk tall. They work hard, play hard and tell it like it is. Or try to.

Their problem? Locked-jaw. Tight mouth.

Words of more than one syllable get

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

trapped behind their teeth where I imagine they build up like plaque. Those Tom, Dick or Harry's finally sidle into the dentist when the pressure of holding back a semi-masticated word mountain gets too much. On 'Open

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

wide', the rugged manly jaw cracks and out falls five years worth of verbal decay.

Now locked-jaw may be OK if your preferred communication style is nod, grunt, nah, maybe, yeah, seen me socks? or chuck us a b

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

er. But a tad sad if you're aspiring to something more.

And it's even sadder to hear potentially good speakers puree their speech pre-delivery by forcing it through clenched teeth.

Providing your spea

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

king equipment is in sound working order, I can only think of one legitimate reason for not opening your mouth while talking. That is you have badly fitting false teeth. If that's true, I'm sorry.

My Mo

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

her had false teeth. The story of how her real teeth were taken out and the ill-fitting dentures came to plague her life is too long for here. It happened in the dark ages of lousy to non-existent dental care many deca

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

des ago. Suffice to say her teeth were not made for talking. Until a kind dental specialist intervened, they clicked and clacked independently providing an interesting percussive counterpoint to anything she tried to s

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

y.

So do you lock your jaw or clench your teeth while talking?
If you do and want to change these articulation or diction exercises will help.
You'll probably be familiar with some of them. As they l

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

ook a bit odd when observed, you may want to do them in privacy.

Firstly you need to loosen your jaws. The easiest way to do this is through yawning. Let your bottom jaw drop as far as you can without strainin

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

and close it again. Repeat 5 times. As a variation add sound. Say 'ahhhhhhhhhhh' for as long as you can on one breath.
Now try sounding the remaining vowels. Let each one go freely and fully from your relaxed mou

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

th for the duration of one breath.

Next push your jaw from side to side with your mouth open and relaxed. Make it go at least five times left and then right as far you can without strain.

Your tongue

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

needs a work out too. Open your mouth. Extend your tongue as far as possible and sweep completely around your lips to the left and then back. Now repeat but sweep to the right. Repeat 5 times. Another variation is do t

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

is behind closed lips. Firstly sweep around the outside of your teeth, left and right. Then do it again but sweep around the inside of your teeth. Be sure to push your tongue right into all the corners.

When y

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ou've done all of those you're ready for a set of tongue twisters. There are many of these focusing on either single letter or specific letter combinations cleverly designed to make us really work.
I've included a

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

selection here to get you started. There are more on my diction exercises web page here.
Three tips before you start to ensure

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

you get the best out of your time.

Start slowly
Carefully say each word making sure you hear the beginning and the end as well as sounding all internal vowel or consonant combinations c

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

early.

Only when you have mastered at least two good run throughs try going faster.

Lucy lingered, looking longingly for her lost lap-dog.

Four furious friends fough

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

t for the phone

Reading and writing are richly rewarding.

Red leather, yellow leather...
Red lorry, yellow lorry...

Vincent vowed vengeance very vehemently.
<

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

R> The pay-off of articulation exercises is clear speech. Good diction is NOT about changing your accent or making you 'talk posh'. It is about clarity - making sure what you say is heard. You do not need to mange you

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

r words behind clenched teeth. Learn to open your mouth and tell it like it really is.

Yes, the opening is a shameless exaggeration. There are many beautifully spoken, literate and articulate men in New Zealand

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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