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EIGRP is a major topic for your CCNA and CCNP studies, and one basic skill you’ll need to pass your Cisco certification exams is to identify situations where y

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

ou need to enable or disable split horizon. EIGRP commands tend to be a little different than those used with other protocols, so let’s take a look at how EIG

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

RP and split horizon interoperate.

R1 is our hub router, with R2 and R3 as the spokes. There are no subinterfaces, and each router is advertising a single lo

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

pback network using its router number for each octet. R1 will see both R2 and R3’s loopback network, but the spokes will not have a route to the other spoke’s

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

loopback. “show ip route eigrp” verifies this.

R1#show ip route eigrp

2.0.0.0/32 is subnetted, 1 subnets

D 2.2.2.2 [90/2297856] via 172.12.123.2, 0

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

:03:29, Serial0

3.0.0.0/32 is subnetted, 1 subnets

D 3.3.3.3 [90/2297856] via 172.12.123.3, 00:03:29, Serial0

R2#show ip route eigrp

1.0.0.0/32 is su

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

bnetted, 1 subnets

D 1.1.1.1 [90/2297856] via 172.12.123.1, 00:05:20, Serial0

R3#show ip route eigrp

1.0.0.0/32 is subnetted, 1 subnets

D 1.1.1

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

1 [90/2297856] via 172.12.123.1, 00:07:54, Serial0

EIGRP runs split horizon by default, making it impossible for R1 to forward an advertisement to R2 regardin

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

g R3’s loopback. Likewise, R1 cannot advertise R2’s loopback address to R3. We could configure two subinterfaces on R1 to resolve this issue, but here we’re g

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ing to disable split horizon instead.

R1(config)#int serial0

R1(config-if)#no ip split-horizon ?

eigrp Enhanced Interior Gateway Routing Protocol (EIGRP)

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

R1(config-if)#no ip split-horizon eigrp ?

<1-65535> Autonomous system number

R1(config-if)#no ip split-horizon eigrp 100

04:10:02: %DUAL-5-NBRCHANGE:

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

IP-EIGRP 100: Neighbor 172.12.123.2 (Serial0) is down: split horizon changed

04:10:02: %DUAL-5-NBRCHANGE: IP-EIGRP 100: Neighbor 172.12.123.3 (Serial0) is do

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

n: split horizon changed

04:10:25: %DUAL-5-NBRCHANGE: IP-EIGRP 100: Neighbor 172.12.123.2 (Serial0) is up: new adjacency

04:10:37: %DUAL-5-NBRCHANGE: IP-EIGR

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

P 100: Neighbor 172.12.123.3 (Serial0) is up: new adjacency

Note that disabling split horizon resulted in the EIGRP adjacencies being torn down. They came ba

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

k up 20 – 35 seconds after being torn down according to the timestamps, but that’s a good detail to keep in mind!

The routing tables of each spoke should now

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

show the loopback network configured on the remote spoke.

R2#show ip route eigrp

1.0.0.0/32 is subnetted, 1 subnets

D 1.1.1.1 [90/2297856] via 172.12.

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

23.1, 00:00:02, Serial0

3.0.0.0/32 is subnetted, 1 subnets

D 3.3.3.3 [90/2809856] via 172.12.123.1, 00:00:02, Serial0

R3#show ip route eigrp

1.0.0.0/

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

32 is subnetted, 1 subnets

D 1.1.1.1 [90/2297856] via 172.12.123.1, 00:00:02, Serial0

2.0.0.0/32 is subnetted, 1 subnets

D 2.2.2.2 [90/2809856]

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

ia 172.12.123.1, 00:00:02, Serial0

Be careful when disabling split horizon. In this scenario, R1 can and will advertise routes out Serial0 that were learned

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

about on that interface in the first place, and that’s not always desirable. Split horizon is enabled by default for a reason, so be careful when disabling it

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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