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When arcade games gained popularity in the 1970s, they were the traditional type like the first pinball games, Pac-Mac

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

, Pong, and Space Invaders. However, over time, the creators of these games realized they had to innovate and improve

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

constantly to retain the attention of their players. This led to them diversifying into games like the High Impact Foo

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

ball game series. This was a completely new format for arcade games. However, these games did not do as well as their

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

ancestors. Perhaps players took time to adjust to them.

It was not until the release of basketball arcade games that

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

this type of game really caught on. The first that really took the arcade games by storm was NBA Jam. This genre got n

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

ticed immediately with its release and became popular worldwide.

NBA Jam was unique in a lot of ways. First of all it

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

was more expensive than the other games, where finishing a game required no less than $2. It was also the very first

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

game that used real teams, real players with their real names, with the digitized version of these players playing the

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

game on screen.

Playing the game was akin to watching a game on TV, only better, since here the game players could ma

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

ke control every move of their favourite basketball players. More so, one could defy gravity to make them do what a pl

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

ayer wanted them to do. This has been one of the criticisms of the game, that it featured unrealistic effects, with th

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

players flying as much as their heights to score a point. Fans of the game however maintained, that this was actually

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

a great high.

However, the game continued to climb on the popularity charts and featured basketball greats of their

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

times like Karl Malone, Chris Webber, Colbert Cheaney, Jeff Hornacek, David Robinson, Charles Oakley among others. Aft

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

r a time people discovered other features of the game like Easter eggs and other special features to be activated by u

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

se of buttons and joysticks.

The game saw many sequels and spin-offs, including the NBA Jam: Tournament Edition, NBA

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

Jam Extreme of 1996 and even a 3D version of the game featuring a commentary. The other games in the line were NBA Han

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

time and NBA Hangtime Extreme. A college version of the game, called College Slam was also introduced in 1995.

The hu

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

ge success of basketball games also gave rise to other sports games, which centred on games like football and baseball

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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