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You have watched it on the TV show CSI, and noted how CSI technicians collect evidence from a crime scene in order determine the who, w

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

hat, when, where, why, and how involved in a crime.

In a science called physical forensic science, there are four aspects involved. In this

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

rticle, I will define the four aspects of physical forensic science so that the next time you watch CSI, you will have a better underst

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

anding of what police scientists talk about.

What is physical forensic science?

Searching for trace evidence, identifying the type of

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

firearm used by studying its projectile, studying the handwriting of a signature on a document, and analyzing the ridges of fingerprints under

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

a microscope all are a part of the physical aspect of forensic science.

Trace evidence

Trace evidence refers to any small ite

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

of evidence such as glass, paint, fiber, hair, or soil. Such evidence puts the suspect at the crime scene or in direct contact with the vict

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

im. Matching glass shards found on the victim of a hit-and-run vehicle accident to glass shards taken from the broken turn signal lamp of the

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

suspect’s car is a good example.

Firearms Identification

All you CSI: Miami fans know that this is right up Caleigh Duquesne’

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

s alley. Firearms identification involves the examination of firearms and the bullets they fire, including ammunition, shell casings,

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

hotgun shells, and fired bullets. Police scientists use microscopes or varying types of chemical analysis to identify the type of gun used to

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

commit a crime and match any bullets fired from that weapon or shell casings to a weapon of interest.

Document Analysis

Whenever an

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

mportant document whose handwriting or authenticity is in question, a document analyst uses handwriting analysis to compare handwriting sample

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

s to questionable documents or signatures. Document analysis also may involve analyzing the chemical and physical properties of papers

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

and inks or exposing indented writing--the indentations made on the page underneath one that was written on. In addition, document ana

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

lysis also includes typewritten and photocopied documents that may have been altered.

Fingerprint Analysis

Fingerprint analysts
ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust
compare prints found at a crime scene to the fingers, palms, or soles of potential suspects. A print found at a crime scene can be compared
y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products
with another print stored in a database such as the FBI’s Automated Fingerprint Identification System (AFIS) or from a suspect, victim, or bys
.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
ander.

Hopefully, all four of these aspects of physical forensic science will give you a clearer picture of what is involved. All law enforc
elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip
ement crime labs use these methods to help bring a crook to justice.

For those of you who are science buffs, this article is food for thought

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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Actual - Discovering Physical Forensic Science

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